DNA ploidy, nuclear grade and architectural changes in ductal carcinoma in situ and in invasive female breast cancer: a contributory study for the model of disease progression / Ploidia de DNA, grau nuclear e alterações arquiteturais no carcinoma in situ e no carcinoma ductal invasivo da mama feminina: uma contribuição para o estudo do modelo de progressão de doença

AUTOR(ES)

Francisco Ribeiro de Moraes

DATA DE PUBLICAÇÃO

2005

RESUMO

Carcinogenesis is a multiple stage phenomenon. Epidemiologic evidence indicates that progression to invasive breast cancer begins in hyperplastic states of the epithelium passing by in situ carcinoma. The actual relationship that exists between ductal carcinoma in situ and invasive ductal carcinoma of the breast and the factors that lead to the tumor invasion process are questions that remain unanswered in the literature. Four models have been developed to explain the progression of the neoplastic disease in the breast tissue. Three of them propose that there is a direct pathway of progression from ductal carcinoma in situ to invasive carcinoma. The fourth one suggests that there is a common precursor lesion and both carcinoma in situ and invasive carcinoma progress in an independent fashion with no relationship between each other. The present work retrospectively studied 46 tumor tissues of the female breast with coexisting ductal carcinoma in situ and ductal invasive carcinoma. DNA ploidy as well as nuclear were determined in both lesions. The architectural pattern of the in situ component and the degree of tubule formation of the invasive component were determined also. Our results showed that there are no statistically significant differences in both nuclear parameters studied (DNA ploidy, k=0,713,p<0,001; nuclear grade, k=0,5018, p=0,0002). When we compared the architectural features of ductal carcinoma in situ with the degree of tubule formation in the invasive component we found a statistically significant different between the groups (p=0,1033). The results lead us to conclude that the nuclear features of a given invasive breast cancer are possibly determined in a preinvasive level, while architectural changes probably develop in a late stage, after the acquisition of the invasive phenotype.

ASSUNTO(S)

neoplasias (mamárias) disease progression histology (classification) carcinoma of the breast dna (ploidy) doenças (desenvolvimento) carcinoma carcinoma dna (quantificação) histologia (classificação)

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