Diterpenos casbanos e acetofenonas de Croton nepetaefolius (Euphorbiaceae)

AUTOR(ES)

Santos, Hélcio Silva, Mesquita, Francisca Maria Rodrigues, Lemos, Telma Leda G., Monte, Francisco Jose Queiroz, Braz-Filho, Raimundo

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2008

RESUMO

Croton nepetaefolius is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. The present work deals with the chromatographic analysis of the ethanolic extract of Croton nepetaefolius stalk. It allowed the isolation and characterization of two diterpenoids named 1,4-dihydroxy-2E,6E,12E-trien-5-one-casbane and 4-hydroxy-2E,6E,12E-5-one-casbane, two acetophenones named 2-hydroxy-4,6-dimethoxyacetophenone and 2-hydroxy-3,4,6-trimethoxyacetophenone and the steroids 3-O-b-D-glucopiranosylsitosterol and a mixture of b-sitosterol and stigmasterol. Structural elucidation was done on the basis of spectral data, mainly high field NMR and EIMS.

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