Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses
AUTOR(ES)
Chan, Stephen Y.
FONTE
American Society for Microbiology
RESUMO
Since the Marburg (MBG) and Ebola (EBO) viruses have sequence homology and cause similar diseases, we hypothesized that they associate with target cells by similar mechanisms. Pseudotype viruses prepared with a luciferase-containing human immunodeficiency virus type 1 backbone and packaged by the MBG virus or the Zaire subtype EBO virus glycoproteins (GP) mediated infection of a comparable wide range of mammalian cell types, and both were inhibited by ammonium chloride. In contrast, they exhibited differential sensitivities to treatment of target cells with tunicamycin, endoglycosidase H, or protease (pronase). Therefore, while they exhibit certain functional similarities, the MBG and EBO virus GP interact with target cells by distinct processes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=112022Documentos Relacionados
- Infection and Activation of Monocytes by Marburg and Ebola Viruses
- Inactivation of Lassa, Marburg, and Ebola viruses by gamma irradiation.
- Vaccines protect monkeys against Marburg and Ebola viruses
- Physicochemical inactivation of Lassa, Ebola, and Marburg viruses and effect on clinical laboratory analyses.
- Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Ebola and Marburg Viruses Using Recombinant Nucleoproteins
