Distinct forms of short-term plasticity at excitatory synapses of hippocampus and neocortex

AUTOR(ES)

Castro-Alamancos, Manuel A.

FONTE

The National Academy of Sciences of the USA

RESUMO

The expression of short- and long-term synaptic plasticity varies strongly across pathways in the central nervous system. Differences in the properties of transmitter release may underlie some of this variability. Here we compared the short-term plasticity displayed by a neocortical and a hippocampal pathway in vitro, and observed dramatic differences. Conditions known to increase transmitter release probability were more effective in hippocampus, while conditions known to decrease release probability were similarly effective in both pathways. The effects of the irreversible open-channel blocker of N-methyl-d-aspartate receptors, MK-801, implied that synapses in the neocortical pathway have a relatively high probability of transmitter release as compared with synapses in the hippocampal pathway. Differences in release probability may explain the pathway-specific variance in short- and long-term synaptic plasticity.

Documentos Relacionados

• Distinct short-term plasticity at two excitatory synapses in the hippocampus
• Very short-term plasticity in hippocampal synapses
• Short-term synaptic enhancement and long-term potentiation in neocortex.
• Long-term but not short-term plasticity at mossy fiber synapses is impaired in neural cell adhesion molecule-deficient mice
• Effects of cytochalasin treatment on short-term synaptic plasticity at developing neuromuscular junctions in frogs.