Dissolution test for glibenclamide tablets
AUTOR(ES)
Gianotto, Elisabeth Aparecida dos Santos, Arantes, Renata Pires, Lara-Filho, Maurilio José, Casimiro Filho, Alexandre Cezar Saraiva, Fregonezi-Nery, Marlene Maria
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2007-10
RESUMO
The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r² = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market.
Documentos Relacionados
- Development and validation of a dissolution test for telithromycin in coated tablets
- Development and validation of a dissolution test for primaquine/polyethylene oxide matrix tablets
- Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets
- Development of dissolution method for benznidazole tablets
- Test of dissolution and comparison of in vitro dissolution profiles of coated ranitidine tablets marketed in Bahia, Brazil
