Disequilibrium, Selection, and Recombination: Limits in Two-Locus, Two-Allele Models
AUTOR(ES)
Hastings, Alan
RESUMO
All possible combinations of equilibria and fitnesses in two-locus, two-allele, deterministic, discrete-generation selection models are enumerated. This knowledge is used to obtain limits (which can be calculated to arbitrary precision) to the relationships among disequilibrium, selection and recombination for fixed values of allele frequencies. In all cases, the inequality|rD| < s/10 holds, where r is recombination and D is disequilibrium, and all selection coefficients lie between 1 - s and 1 + s times that of the double heterozygote. Linear programming techniques are used to calculate the minimum strength of selection needed to explain several observed nonzero values of D reported in the literature. One conclusion is that the failure to observe nonzero values of D is not surprising.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1214465Documentos Relacionados
- Four Simultaneously Stable Polymorphic Equilibria in Two-Locus Two-Allele Models
- Multilocus Population Genetics with Weak Epistasis. I. Equilibrium Properties of Two-Locus Two-Allele Models
- Limits to the Relationship among Recombination, Disequilibrium and Epistasis in Two-Locus Models
- Disequilibrium in Two-Locus Mutation-Selection Balance Models
- Epistasis Can Facilitate the Evolution of Reproductive Isolation by Peak Shifts: A Two-Locus Two-Allele Model
