Discordance between T-Cell Receptor Expression and Effector Function in Mice Infected with Histoplasma capsulatum

AUTOR(ES)

Deepe, George S.

FONTE

American Society for Microbiology

RESUMO

Vβ10+ and Vβ14+ T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, Vβ1+ and Vβ8.1+ cells were sporadically increased. Elimination of Vβ10+ and Vβ14+ cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of Vβ families does not necessarily signify a key role in host defense.

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