Diphencyprone as a therapeutic option in cutaneous metastasis of melanoma. A single-institution experience

AUTOR(ES)

Gibbons, Ivana Lameiras, Sonagli, Marina, Bertolli, Eduardo, Macedo, Mariana Petaccia de, Pinto, Clovis Antonio Lopes, Duprat Neto, João Pedreira

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2018-03

RESUMO

Abstract: Diphencyprone has been reported as a local immunotherapy for cutaneous melanoma metastases. We aim to report cases of melanoma patients treated with diphencyprone in a single Brazilian institution and highlight their outcomes. Since 2012, we have treated 16 melanoma patients with cutaneous metastases with topical diphencyprone. To date, we have had 37.5% of complete response, 25% of partial responses, and 31.25% patients without any response. Treatment was well tolerated and local toxicity was easily controlled. We believe topical diphencyprone is a feasible treatment that can be another option for treating melanoma patients, especially in cases of in-transit or extensive disease.

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