Diffusion-limited kinetics of the solution–solid phase transition of molecular substances
AUTOR(ES)
Petsev, Dimiter N.
FONTE
The National Academy of Sciences
RESUMO
For critical tests of whether diffusion-limited kinetics is an option for the solution–solid phase transition of molecular substances or whether they are determined exclusively by a transition state, we performed crystallization experiments with ferritin and apoferritin, a unique pair of proteins with identical shells but different molecular masses. We find that the kinetic coefficient for crystallization is identical (accuracy ≤7%) for the pair, indicating diffusion-limited kinetics of crystallization. Data on the kinetics of this phase transition in systems ranging from small-molecule ionic to protein and viri suggest that the kinetics of solution-phase transitions for broad classes of small-molecule and protein materials are diffusion-limited.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=298680Documentos Relacionados
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