Differential response of the bvg virulence regulon of Bordetella pertussis to MgSO4 modulation.
AUTOR(ES)
Scarlato, V
RESUMO
Magnesium sulfate is known to repress the expression of the virulence factors of Bordetella pertussis that are coordinately regulated by the bvg locus. We have tested the time required by MgSO4 to repress the synthesis of several bvg-regulated mRNA species and found that the promoters of the virulence genes (pertussis toxin, adenylate cyclase, and filamentous hemagglutinin) are repressed in 6 min, while the autogenously regulated promoters of the bvg locus (P1, P3, and P4) are repressed only several hours later. These data show a differential behavior between regulated and autoregulated genes of the bvg regulon.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=209252Documentos Relacionados
- Protection of Mycobacterium smegmatis from Ethambutol and Streptomycin Inhibition by MgSO4 and Polyamines
- Differential Regulation of Bvg-Activated Virulence Factors Plays a Role in Bordetella pertussis Pathogenicity
- Bordetella pertussis TonB, a Bvg-Independent Virulence Determinant
- Solubility measurement and solid-liquid equilibrium model for the ternary system MgBr2 + MgSO4 + H2O at 288.15 K
- Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis
