Differential Modulatory Effects of Clarithromycin on the Production of Cytokines by a Tumor
AUTOR(ES)
Sassa, Kazuhiko
FONTE
American Society for Microbiology
RESUMO
In vitro treatment with clarithromycin inhibited the expression of the matrix metalloproteinase-9, transforming growth factor β, and tumor necrosis factor alpha genes in 13762NF rat mammary adenocarcinoma cells. Transient enhancement, rather than inhibition, was observed for the interleukin-6 gene, and no significant change was observed for the tissue inhibitor of metalloproteinase-2 gene. Such an effect was not observed for cefotiam or gentamicin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89561Documentos Relacionados
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