Diethyl Selenodiglycolate: An Eco-Friendly Synthetic Antioxidant with Potential Application to Inflammatory Disorders

AUTOR(ES)

Pinatto-Botelho, Marcos F.; Silva, Railmara P. da; Archilha, Marcos V. L. R.; Giroldo, Lilian; Kuznetsov, Aleksey E.; Meotti, Flávia C.; Santos, Alcindo A. dos

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2020-06

RESUMO

This study describes a single step, high yield and purity, ecofriendly and scalable procedure to prepare a selenium derivative (diethyl selenodiglycolate). Diethyl selenodiglycolate rapidly reduces hypochlorous acid (HOCl, second-order rate constant of 7 × 107 M−1 s−1) to generate its corresponding selenoxide. In activated HL-60 cells, diethyl selenodiglycolate selectively reacted with HOCl (half maximal inhibitory concentration (IC50) = 23.07 µM) but not with superoxide anion radical or hydrogen peroxide without any cytotoxicity. These results show that this synthetically simple selenide reacts in a very efficient and specific way with the harmful pro-oxidant HOCl being a promising compound to be applied in oxidative inflammatory-related conditions.

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