Diagnostic challenges of single plaque-like lesion paucibacillary leprosy

AUTOR(ES)

Barbieri, Raquel Rodrigues, Sales, Anna Maria, Illarramendi, Ximena, Moraes, Milton Ozório, Nery, José Augusto da Costa, Moreira, Suelen Justo Maria, Sarno, Euzenir Nunes, Machado, Alice de Miranda, Bozza, Fernando Augusto

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

14/10/2014

RESUMO

The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy were classified as HP/MP, eight of which were qPCR negative. In the LP/OD (n = 19), two out of eight untreated patients showed positive qPCR results. In the absence of typical histopathological features, qPCR may be utilised to aid in final patient diagnosis, thus reducing overtreatment and delay in diagnosis.

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