Diagnostic and therapeutic problems in two patients with antiphospholipid antibodies, heart valve lesions, and transient ischaemic attacks.

AUTOR(ES)

Asherson, R A

RESUMO

Two young women (aged 32 and 25 years) with systemic lupus erythematosus and heart valve lesions in association with antiphospholipid antibodies are presented. In addition to the presence of the 'lupus anticoagulant' and false positive Venereal Disease Research Laboratory (VDRL) tests, both patients had high levels of IgG anticardiolipin antibodies. The first patient additionally had contraceptive induced chorea, chorea gravidarum, seven miscarriages, livedo reticularis, pulmonary embolism, and thrombocytopenia and developed culture negative endocarditis as well as hypertension. The second patient, who had presented with hypertension, developed aortic and mitral regurgitation, suspected myocarditis, manifested transient ischaemic attacks, and responded well to anticoagulation and steroid treatment.

Documentos Relacionados

• Angiographic investigation of patients with transient ischaemic attacks.
• Stroke and transient ischaemic attacks.
• Cost-effective investigation of patients with suspected transient ischaemic attacks.
• The prognosis of hospital-referred transient ischaemic attacks.
• Disseminated intravascular coagulation, antiphospholipid antibodies, and ischaemic necrosis of extremities.