Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator
AUTOR(ES)
Nunes, Vinicius Rodrigues Taranto, Vidigal, Paula Vieira Teixeira, Pereira, Márcio Tadeu, Ladeira, Luís Carlos Duarte, Barbuto, Rafael Calvão, Duval-Araujo, Ivana
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2017-04
RESUMO
Abstract Purpose: To describe a new model of actinic enteritis that does not use radiotherapy machines. Methods: Sixteen Wistar rats were divided into four groups, consisting of four animals each: control (group A), two weeks after irradiation (group B), five weeks after irradiation (group C) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal. Results: In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon. Conclusion: We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis.
Documentos Relacionados
- Comparative Absorption of Cobalt-60 by Upper and Lower Epidermis of Leaves. 123
- Lifespans of Mice as Affected by Continuing Irradiation from Cobalt-60 Accumulated Ancestrally and under Direct Irradiation
- Preoperative cobalt60 irradiation delays the healing of rectal anastomoses in rats
- Effects of gamma radiation from Cobalt-60 on pequi fruits (Caryocar brasiliense Camb.)
- Advancement in liver laparoscopic resection – development of a new surgical device