Development of a mouse computational model for MCNPx based on Digimouse (r) images and dosimetric assays

AUTOR(ES)

Mendes, Bruno Melo, Almeida, Iassudara Garcia de, Trindade, Bruno Machado, Fonseca, Telma Cristina Ferreira, Campos, Tarcísio Passos Ribeiro de

FONTE

Braz. J. Pharm. Sci.

DATA DE PUBLICAÇÃO

20/04/2017

RESUMO

ABSTRACT The aim of this study was to create and test a new mice 3D-voxel phantom named DM_BRA for mice and human first-estimation radiopharmaceutical dosimetry. Previously, the article reviews the state-of-art in animal model development. Images from Digimouse CT database were used in the segmentation and on the generation of the voxelized phantom. Simulations for validation of the DM_BRA model was performed at 0.015, 0.1, 0.5, 1 and 4 MeV photons with heart-source. Specific Absorbed Fractions (SAF) data were compared with literature data. The organ masses of DM_BRA correlated well with existing models based on the same dataset; however, few small organ masses hold significant variations. The SAF data in most simulated cases were statistically equal to a significant level of 0.01 to the reference data.

Documentos Relacionados

• The potential efficacy of Survanta (r) and Seprafilm (r) on preventing intra-abdominal adhesions in rats
• Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activities.
• Development of rRNA-Based PCR Assays for Identification of Burkholderia cepacia Complex Isolates Recovered from Cystic Fibrosis Patients
• Development of an adult mouse model for studies on protection against rotavirus.
• Computational model of the on-alpha ganglion cell receptive field based on bipolar cell circuitry.