Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
AUTOR(ES)
Silva, Breno de Carvalho e, Campos, Lígia Maria Moreira de, Pianetti, Gerson Antônio
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2005-02
RESUMO
A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.
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