Development and application of method for the 3-chloro-4-(dichloromethyl)-2[5H]- furanone (MX) / Desenvolvimento e aplicação de método para a determinação do 3-cloro-4-(diclorometil)-5-hidroxi-2[5H]-furanona (MX) em água potável

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

A by-product of chlorination in water is the 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX), a toxic compound which has been the subject of recent studies. Although MX has been found at low concentrations (ng/L), it accounts for approximately 50% of the total mutagenicity in drinking water. In this study, a method was developed to analyze MX at trace leveI in chlorinated waters. The MX extraction efficiency was evaluated using three different techniques: solid phase extraction (SPE), solid phase microextraction (SPME) and liquid-liquid extraction (LLE). The LLE technique provided higher recovery with value of 50% at concentrations ≤ 50 ng/L. A simple and fast procedure involving on-line based trimethylsilyl derivatization for the quantitative analysis of MX by gas chromatography with mass spectrometry (GCIMS) is proposed. Good precision and low limit of detection of the method allowed its application in real water samples. The reliable MX identification and quantification were obtained due to the use of the mass spectrometry. Since the instrumental limit of detection was equal to 3.0 µg/L, the samples had to be concentrated to 2000 times the original concentration. The optimized method was applied to water samples collected before and after chlorination process in water suppliers located in São Paulo City, Brazil. Concentrations of MX in those samples ranged from 3 to 22 ng/L which are similar to those detected in other countries.

ASSUNTO(S)

drinking water análise toxicológica cromatografia em fase gasosa mx mx espectrometria de massas Água potável gas chromatography mass spectrometry

ACESSO AO ARTIGO

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