Determination of Aspirin Using Chemiluminescence System of Tris(1,10 phenanthroline)Ruthenium(II)-Cerium(IV)

AUTOR(ES)

Mokhtari, Ali, Keyvanfard, Mohsen, Emami, Iraj, Delouei, Nastaran J., Pishkhani, Hatameh F., Ebrahimi, Aida, Karimian, Hossein

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2016-03

RESUMO

A new chemiluminescence (CL) method has been proposed for the simple determination of aspirin (acetylsalicylic acid, ASA). The method is based on the enhancement effect of ASA in the CL reaction of tris(1,10 phenanthroline)ruthenium(II), Ru(phen)32+, with cerium(IV) (CeIV) in acidic medium. Under optimum conditions, the CL intensity was proportional to the concentration of the drug in solution over the range 0.72-72.00 µg mL-1 ASA. The limit of detection (S/N = 3) was 0.45 µg mL-1. In the method proposed, limit of detection was at least 30 times lower than the therapeutic concentration of ASA. The percent of relative standard deviation for determination of 10 replicates at level of 28.8 µg mL-1 of ASA was 5.8% and the minimum sampling rate was 30 samples per hour. Effects of some ingredients were investigated and the proposed method was applied successfully for the determination of ASA in pharmaceutical formulations and plasma samples. A time resolve CL approach was used to reduce the effect of interferences from cysteine and ascorbic acid in plasma samples. The possible CL reaction mechanism was also discussed.

Documentos Relacionados

• Syntheses, characterization and antifungal activity of tris(1,10-phenanthroline)iron(ii) bis(n-r-sulfonyldithiocarbimate)zincate(ii)
• Nuclease activity of 1,10-phenanthroline-copper: sequence-specific targeting.
• SAIS DE TETRAFENILFOSFÔNIO E TRIS(1,10-FENANTROLINA)FERRO(II) DE COMPLEXOS ANIÔNICOS DE DIBUTILESTANHO(IV) COM DITIOCARBIMATOS: SÍNTESE, CARACTERIZAÇÃO E ATIVIDADE ANTIFÚNGICA
• The influence of reducing agent and 1,10-phenanthroline concentration on DNA cleavage by phenanthroline + copper.
• Development of a Selective and Sensitive Sensor for Urate Determination Based on Tris(1,10-phenantroline)copper(II) Bis(tetracyanoquinodimethanide) Adsorbed on Carbon Nanotubes