Determinação experimental dos perfis de espalhamento de tecidos mamários (normais e alterados) e sua potencialidade como ferramenta de diagnóstico / Experimental determination of scattering profiles from breast tissues (normal and altered) and its potentiality as a diagnostic tool.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Angular distribution of photons scattered by tissues (scattering profile) gives detailed information of structures within them and provides an alternative mean of distinguishing pathologies. The proposal of this work was to develop an experimental procedure to determine scattering profiles from breast tissues (normal and neoplastic) and to correlate the information contained in these profiles with histopathological information. The scattering profiles were measured in the interval of momentum transfer 0,2 ? ? ? 6,2 nm-1, using a powder diffractomer apparatus (Siemens D-5005), with copper anode and operation in reflection mode. The breast samples were previously histopathologically classified as normal tissues, fibroadenomes and carcinomas. The measured angular distribution was corrected by attenuation, geometric effect and the angular variation of the incident beam. The effectiveness of the experimental procedure was validated through the use of water reference data. The results shown that, scattering profile is unique impression of each type of tissue, being correlated with the microscopic morphological features. In the region where ? ? 0,35 nm-1, were statistically verified that the information contained in the scattering profiles allow the differentiation between normal and neoplastic breast tissues.

ASSUNTO(S)

patologia mamária x ray scattering mamografia mammography perfis de espalhamento breast cancer.

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