Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients

AUTOR(ES)

Faria-Pinto, Priscila de, Mendes, Rita Gabriela Pedrosa Ribeiro, Carvalho-Campos, Cristiane de, Maia, Ana Carolina Ribeiro Gomes, Oliveira, Áureo Almeida, Coelho, Paulo Marcos Zech, Vasconcelos, Eveline Gomes

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2010-07

RESUMO

In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.

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