Desenvolvimento de procedimento utilizando processo de soldagem plasma para confecção de sementes de Iodo125 / Development of a procedure using plasma welding process to produce 125I seeds

AUTOR(ES)

Anselmo Feher

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

13/12/2006

RESUMO

The prostate cancer, which is the second cause of death by cancer in men, overcome only by lung cancer, is a problem of public health in Brazil. Brachytherapy is among the possible available treatments for prostate cancer, in which small seeds containing 125I radioisotope are implanted in the prostate. The seed consists of a titanium sealed capsule with 0.8 mm external diameter and 4.5 mm length, containing a central silver wire with adsorbed 125I. The plasma arc welding is one of the viable techniques for the sealing process. The equipment used in this technique is less costly than in other processes. The main objective of this work was the development and the validation of the welding procedure using plasma welding process and the elaboration of a sealing routine according to Good Manufacturing Practices. The development of this work has presented the following phases: cut and cleaning of the titanium material, determination of the welding parameters, development of a device for holding the titanium tube during the welding process, validation of sealed sources according to ISO 2919 Sealed Radioactive Sources - General Requirements and Classification, leakage test according to ISO 9978 Sealed Radioactive Sources - Leakage Test Methods and metallographics assays. The developed procedure, to seal 125I seeds using plasma welding process, has shown to be efficient, satisfying all the established requirements of ISO 2919. The results obtained in this work have given the possibility to establish a routine production process according to the orientations presented in resolution RDC nº 59 - Good Manufacturing Practices to Medical Products of the ANVISA - National Agency of Sanitary Surveillance.

ASSUNTO(S)

plasma arc welding brachytherapy braquiterapia fios iodine 125 iodo-125 materiais de vedação neoplasias neoplasms prata próstata prostate radiation source implants sealing materials silver titânio titanium wires

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