Dermatitis Herpetiformis IMMUNOLOGIC CONCOMITANTS OF SMALL INTESTINAL DISEASE AND RELATIONSHIP TO HISTOCOMPATIBILITY ANTIGEN HL-A8
AUTOR(ES)
Gebhard, Roger L.
RESUMO
In the present study the relation between the gluten-sensitive intestinal lesion observed in dermatitis herpetiformis (DH) and in gluten-sensitive enteropathy (coeliac sprue) (GSE) was analyzed. Jejunal IgA synthesis in DH was estimated from the extent of incorporation of [14C]leucine into IgA in jejunal biopsy specimens during short-term in vitro culture. Patients with DH have significantly elevated incorporation values as compared to normal control individuals (18,880±13,614 vs. 5,830±3,190 cpm/mg tissue protein/ 90 min) (P < 0.02) and the degree of elevation correlates well with the degree of morphologic abnormality. Thus patients with DH are similar to patients with GSE where elevated local mucosal IgA synthesis has also been observed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301528Documentos Relacionados
- Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy
- HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy
- Proceedings: Histocompatibility antigen (HL-A 27) and its relation to disease.
- A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice
- The small intestine in dermatitis herpetiformis