Delineamentos experimentais eficientes para estudos de cinética química
AUTOR(ES)
Ferreira, Iuri E. P., Trinca, Luzia A., Ferreira, Cláudia P.
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2014
RESUMO
In this paper we show how to obtain efficient designs of experiments for fitting Michaelis-Menten and Hill equations useful in chemical studies. The search of exact D-optimal designs by using local and pseudo-Bayesian approaches is considered. Optimal designs were compared to those commonly used in practice using an efficiency measure and theoretical standard errors of the kinetic parameter estimates. In conclusion, the D-optimal designs based on the Hill equation proved efficient for estimating the parameters of both models. Furthermore, these are promising with respect to practical issues, allowing efficient estimation as well as goodness-of-fit tests and comparisons between some kinetic models.
Documentos Relacionados
- Estudo comparativo de delineamentos experimentais para estimativas de parâmetros genéticos em erva-mate Ilex paraguariensis A. St. Hil..
- Alternative methods for testing hypotheses in experimental designs.
- Magnetohipertermia para o tratamento de gliomas: estudos experimentais e clínicos
- Extração de β-caroteno de cenouras: uma proposta para disciplinas experimentais de química
- Planejamento e análise de estudos de biequivalência:: comparação de delineamentos do tipo cross-over
