Dehydroepiandrosterone Sulfate Treatment of Mice Modulates Infection with Schistosoma mansoni

AUTOR(ES)

Fallon, Padraic G.

FONTE

American Society for Microbiology

RESUMO

Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05–0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = −0.621 and r = −0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.

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