Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis: case report and literature review

AUTOR(ES)

Rosa, Daniela Dornelles, Pasqualotto, Alessandro C., Quadros, Maurício de, Prezzi, Sérgio Henrique

FONTE

Brazilian Journal of Infectious Diseases

DATA DE PUBLICAÇÃO

2004-08

RESUMO

The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.

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