Deficiency of Coenzyme Q10 in Gingival Tissue from Patients with Periodontal Disease
AUTOR(ES)
Littarru, Gian Paolo
RESUMO
The specific activities of the succinate dehydrogenase-coenzyme Q10 reductase in gingival tissue from patients with periodontal disease have been compared with the corresponding specific activities of normal human periodontal tissue. The gingival biopsies from patients having diseased periodontal tissue showed a deficiency of coenzyme Q10, in contrast to those of the normal periodontal tissue which showed no deficiency. The presence or absence of a deficiency of coenzyme Q10 in the succinate-coenzyme Q10 enzyme system is appraised by determining the specific activity in the absence and again in the presence of exogenous coenzyme Q3. An increase in specific activity of this mitochondrial enzyme system in the presence of exogenous coenzyme Q3 reflects the mitochondrial deficiency of coenzyme Q10. Such increases ranged from 38-120% and averaged 81% for the individuals with periodontal disease, and were highly significant statistically.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389415Documentos Relacionados
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