Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

AUTOR(ES)

Barbosa, Izabela G., Morato, Isabela B., Huguet, Rodrigo B., Rocha, Fabio L., Machado-Vieira, Rodrigo, Teixeira, Antônio L.

FONTE

Rev. Bras. Psiquiatr.

DATA DE PUBLICAÇÃO

29/07/2014

RESUMO

Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD). Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA). Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p < 0.05). There were no significant differences in NT-3 plasma levels between BD patients and controls. Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

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