Daily Variations in Ceftriaxone Pharmacokinetics in Rats
AUTOR(ES)
Rebuelto, M.
FONTE
American Society for Microbiology
RESUMO
The aim of this study was to determine whether the time of day ceftriaxone was administered modified its pharmacokinetics. Ceftriaxone was given intraperitoneally at either 0400, 1000, 1600, and 2200 h to Sprague-Dawley rats synchronized under a light-dark cycle of 12 h of light and 12 h of dark. Pharmacokinetic parameters were analyzed for the presence of a 24-h rhythm. Results showed significant daily variations (P < 0.05) in ceftriaxone clearance, with the highest values during the dark phase. It is concluded that time-dependent variations in ceftriaxone pharmacokinetics may affect the therapeutic efficacy of current once-daily dosing schedules.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=151780Documentos Relacionados
- Comparative pharmacokinetics of YM-13115, ceftriaxone, and ceftazidime in rats, dogs, and rhesus monkeys.
- Pharmacokinetics of ceftriaxone in humans.
- Ceftriaxone pharmacokinetics in newborn infants.
- Pharmacokinetics of Ceftriaxone in Pediatric Patients With Meningitis
- Effects of diclofenac on ceftriaxone pharmacokinetics in humans.
