Cytotoxic Chalcones from Desmodium oxyphyllum

AUTOR(ES)

Gao, Xue-Mei, Wang, Huan, Li, Yin-Ke, Ji, Bing-Kun, Xia, Cong-Fang, Yang, Juan-Xia, Zhou, Min, Ye, Yan-Qing, Hu, Qiu-Fen

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

Three new chalcones were isolated from Desmodium oxyphyllum. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-nuclear magnetic ressonance techniques. The compounds were evaluated for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). The results showed that the compounds exhibited weak cytotoxicity against some selected cell lines with IC50 values ranging from 3.6 to 8.9 μM.

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