Cytotoxic Alkaloids from Hippeastrum solandriflorum Lindl.
AUTOR(ES)
Carvalho, Kaline R., Silva, Alison B., Torres, Maria Conceição M., Pinto, Francisco Chagas L., Guimarães, Larissa A., Rocha, Danilo D., Silveira, Edilberto R., Costa-Lotufo, Letícia V., Braz‑Filho, Raimundo, Pessoa, Otília Deusdênia. L.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2015-10
RESUMO
One new alkaloid, 2α-10bα-dihydroxy-9-O-demethylhomolycorine, in addition to seven others known alkaloids, and 5-(hydroxymethyl)furfural, piscidic acid and eucomic acid, were isolated from the bulbs of Hippeastrum solandriflorum. The structures of all compounds were determined using nuclear magnetic resonance (NMR) spectroscopic techniques: 1H NMR and 13C NMR, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), nuclear Overhauser effect spectroscopy (NOESY), and also the high-resolution electrospray ionization mass spectrometry (EI-HRMS). The cytotoxic activity of all alkaloids was evaluated against three human cancer cell lines (HCT-116, HL-60, OVCAR8 and SF-295) showing IC50 values ranging from 0.01 to 35.7 µM.
