Cyclin D1 triggers autonomous growth of breast cancer cells by governing cell cycle exit.

AUTOR(ES)

Zwijsen, R M

RESUMO

Cyclin D1 controls G1-associated processes, including G0-to-G1 and G1-to-S transitions. This study demonstrates a novel aspect of cyclin D1 as a regulator of the transition between G1 and G0. Overexpression of cyclin D1 in MCF7 breast tumor cells resulted in a continued proliferation under low-serum conditions, whereas nonoverexpressing cells ceased to grow. This difference in growth was due to a reduced exit from G1 to G0 in cyclin D1-overexpressing cells. Our data therefore suggest a model in which cyclin D1 overexpression in tumor cells is responsible for hyperproliferation under growth factor-deprived conditions.

Documentos Relacionados

• Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.
• Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1
• Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1
• Transcriptional Activation of Cyclin D1 Promoter by FAK Contributes to Cell Cycle Progression
• Cell Cycle Arrest and Repression of Cyclin D1 Transcription by INI1/hSNF5