Crystal Morphology Engineering of Pharmaceutical Solids: Tabletting Performance Enhancement
AUTOR(ES)
Mirza, Sabiruddin
FONTE
Springer US
RESUMO
Crystal morphology engineering of a macrolide antibiotic, erythromycin A dihydrate, was investigated as a tool for tailoring tabletting performance of pharmaceutical solids. Crystal habit modification was induced by using a common pharmaceutical excipient, hydroxypropyl cellulose, as an additive during crystallization from solution. Observed morphology of the crystals was compared with the predicted Bravais–Friedel–Donnay–Harker morphology. An analysis of the molecular arrangements along the three dominant crystal faces [(002), (011), and (101)] was carried out using molecular simulation and thus the nature of the host–additive interactions was deduced. The crystals with modified habit showed improved compaction properties as compared with those of unmodified crystals. Overall, the results of this study proved that crystal morphology engineering is a valuable tool for enhancing tabletting properties of active pharmaceutical ingredients and thus of utmost practical value.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2663677Documentos Relacionados
- Molecular interactions in binary solids: crystal structure of a cholesteryl ester solid solution.
- Mass transfer inside oblate spheroidal solids: modelling and simulation
- The elasticity and failure of fluid-filled cellular solids: Theory and experiment
- Archimedean solids: Transition metal mediated rational self-assembly of supramolecular-truncated tetrahedra
- Anisotropic surface chemistry of crystalline pharmaceutical solids