Cross-reacting serum opsonins in patients with meningococcal disease.

AUTOR(ES)

Guttormsen, H K

RESUMO

We have examined the opsonic activity of sera from patients with Neisseria meningitidis (B:15:P1.16) infections against different meningococcal strains, using flow cytometry and luminol-enhanced chemiluminescence. A marked increase in the phagocytosis of ethanol-fixed meningococcal strains of different serogroups, serotypes, and serosubtypes was demonstrated in the presence of convalescence sera compared with acute sera. Convalescence sera also caused a significant increase of leukocyte oxidative metabolism during phagocytosis, as measured by luminol-enhanced chemiluminescence. The sera contained a broad range of opsonins cross-reacting with serogroup A, B, C, W-135, and Y meningococci of different serotypes and serosubtypes, indicating that the cross-reacting opsonins recognized surface epitopes other than those determined by current serotyping schemes.

Documentos Relacionados

• Cross-reacting material in Gaucher disease fibroblasts.
• A circulating substance cross-reacting with antiimidazoline antibodies. Detection in serum in relation to essential hypertension.
• Characterization of a variant prekallikrein, prekallikrein Long Beach, from a family with mixed cross-reacting material-positive and cross-reacting material-negative prekallikrein deficiency.
• Cross-reacting material in genetic variants of haemophilia B
• Analysis of Brucella lipopolysaccharide with specific and cross-reacting monoclonal antibodies.