Correlação das caracteristicas clinicas, histopatologicas e expressão de acido graxo sintase e ErbB2, em carcinomas espinocelulares bucais de pacientes com recidiva local precoce / Correlation among clinical and pathological characterisitics and expressions of FAS and ErbB2 in early recurrent oral squamous cell carcinoma

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Oral squamous cell carcinoma (SCC) recurs locally in about 30% of cases. The recognition of reliable factors may result in the tumor behavior prediction and prevent treatment failures. The purpose of this study was to evaluate the correlation among clinical, histopathological and immunohistochemical features in oral SCC with early local recurrence. Sixty-nine cases of oral SCC without previous treatment for head and neck tumors were selected, being: 23 cases with early local recurrence and 46 cases without recurrence. Clinical data were obtained from the medical records and the histopathological features were assessed according Anneroth?s and Bryne?s histological grading of malignancy. Immunohistochemical reactions for FAS and ErbB2 were performed. Our results showed a male predilection (89.85%), with a mean age of 55.5 years. Although there were no statistical differences, relative risks of 2.62 and 2.89 were observed for smokers and alcohol drinkers have local recurrence, respectively. Significant differences were observed between surgical treatment and local recurrence (p = 0.03). The sum of the Anneroth?s histological grading degrees exceeding 15 was statistically associated to local recurrence (p = 0.03). Lower FAS and more cytoplasmic ErbB2 expression were statistically correlated to local recurrence (p = 0.01). An association between overall survival and alcohol use was observed (p = 0.0028). The parameters keratinization (p <0.0001), mode of invasion (p <0.0001) and lymphoplasmocytic infiltration (p <0.0001) according Anneroth?s histological grading were related to overall survival. More FAS expression was also associated with better overall patients survival (p = 0.0002). Although there was no statistical difference, FAS was related to keratinization (p = 0.08), similar but statistically, keratinization was associated with membrane ErbB2 expression (p = 0.0006). According our results, we suggest the use of Anneroth?s histological grading system as well as the immunohistochemical markers FAS and ErbB2, for best comprehension of OSCC?s behavior

ASSUNTO(S)

prognostico oral cancer immunohistochemistry boca - cancer prognosis imunohistoquimica

ACESSO AO ARTIGO

Documentos Relacionados