Correlação da pressão coloidosmótica com a evolução clínica de cadelas com sepse submetidas a tratamento intensivo / Correlation of colloid osmotic pressure with clinical progress in female dogs with septicemia submitted to intensive therapy

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

17/12/2010

RESUMO

Sepsis induces increased vascular permeability, translocation and albumin loss to extracellular space, resulting in hypoalbuminemia and lower plasma colloid osmotic pressure. This study correlate colloid osmotic pressure with the clinical progress of 41 female dogs presenting severe sepsis or sepsis shock due to pyometra, submitted to ovario-salpingo-hysterectomy. The parameters evaluated were: systolic arterial pressure, urinary debt, blood lactate, venous base excess and colloid osmotic pressure. Samples were collected every three hours during the inpatient period. Laboratorial analysis of colloid osmotic pressure was performed in different timings: group I (clinic criteria, n=21), samples analyzed only after the end of the treatment; and group II (quantitative criteria, n=20): samples analyzed immediately after collection. The parameters were a guide to evaluate the necessity of colloid administration. We found no correlation between the parameters evaluate and the values of colloid osmotic pressure. The administration of colloid presented a non-significant and inversely proportional correlation with SOFA. We concluded that colloid osmotic pressure is not directly correlated with tissue perfusion and colloid administration does not improve tissue perfusion or colloid osmotic pressure, even after the administration of substantial volumes of crystalloid solution.

ASSUNTO(S)

colloid colloid osmotic pressure coloide critical care pressão coloidosmótica sepse sepses terapia intensiva

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