Copper Transport in Mammalian Cells: Special Care for a Metal with Special Needs*

AUTOR(ES)

Kaplan, Jack H.

FONTE

American Society for Biochemistry and Molecular Biology

RESUMO

Copper plays an essential role in human physiology. It is required for respiration, radical defense, neuronal myelination, angiogenesis, and many other processes. Copper has distinct physicochemical properties that pose uncommon challenges for its transport across biological membranes. Only small amounts of copper are present in biological fluids, and essentially none of it exists in a free ion form. These properties and the low redox potential of copper dictate special structural and mechanistic features in copper transporters. This minireview discusses molecular mechanisms through which copper enters and exits human cells.

Documentos Relacionados

• Emergency Preparedness for Vulnerable Populations: People with Special Health-care Needs
• Bundles: meeting clinical information needs*
• Coordinated Care Special Needs Shelter
• Medicaid Managed Care and the Unmet Need for Mental Health Care among Children with Special Health Care Needs
• Falling Short: Continued Challenges in Meeting the Mental Health Needs of Children with Special Health Care Needs