Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa–DPa transcription factor
AUTOR(ES)
De Veylder, Lieven
FONTE
Oxford University Press
RESUMO
New plant cells arise at the meristems, where they divide a few times before they leave the cell-cycle program and start to differentiate. Here we show that the E2Fa–DPa transcription factor of Arabidopsis thaliana is a key regulator determining the proliferative status of plant cells. Ectopic expression of E2Fa induced sustained cell proliferation in normally differentiated cotyledon and hypocotyl cells. The phenotype was enhanced strongly by the co-expression of E2Fa with its dimerization partner, DPa. In endoreduplicating cells, E2Fa–DPa also caused extra DNA replication that was correlated with transcriptional induction of S phase genes. Because E2Fa–DPa transgenic plants arrested early in development, we argue that controlled exit of the cell cycle is a prerequisite for normal plant development.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=125359Documentos Relacionados
- The Plant-Specific Cyclin-Dependent Kinase CDKB1;1 and Transcription Factor E2Fa-DPa Control the Balance of Mitotically Dividing and Endoreduplicating Cells in Arabidopsis
- Role of an Atypical E2F Transcription Factor in the Control of Arabidopsis Cell Growth and Differentiation
- E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
- MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts
- Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.