Continuation of neurogenesis in the hippocampus of the adult macaque monkey
AUTOR(ES)
Kornack, David R.
FONTE
The National Academy of Sciences
RESUMO
We present evidence for continuous generation of neurons, oligodendrocytes, and astrocytes in the hippocampal dentate gyrus of adult macaque monkeys, using immunohistochemical double labeling for bromodeoxyuridine and cell-type-specific markers. We estimate that the relative rate of neurogenesis is approximately 10 times less than that reported in the adult rodent dentate gyrus. Nevertheless, the generation of these three cell types in a discreet brain region suggests that a multipotent neural stem cell may be retained in the adult primate hippocampus. This demonstration of adult neurogenesis in nonhuman Old World primates—with their phylogenetic proximity to humans, long life spans, and elaborate cognitive abilities—establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogenesis in humans and offers new insights into its significance in the adult brain.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=21935Documentos Relacionados
- Opiates inhibit neurogenesis in the adult rat hippocampus
- FGF-2 regulation of neurogenesis in adult hippocampus after brain injury
- Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice
- Spatial processing in the auditory cortex of the macaque monkey
- THE EFFERENT FIBRES OF THE HIPPOCAMPUS IN THE MONKEY
