Constituintes químicos dos galhos de Simaba guianensis subesp. ecaudata (Cronquist)

AUTOR(ES)

Nunomura, Rita de Cássia Saraiva, Pinto, Angelo C., Nunomura, Sergio Massayoshi, Pohlit, Adrian Martin, Amaral, Ana Cláudia Fernandes

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2012

RESUMO

Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound.

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