Consensus of the Brazilian Society of Infectious Diseases and Brazilian Society of Clinical Oncology on the management and treatment of Kaposi's sarcoma

Arruda, Érico, Jacome, Alexandre Andrade dos Anjos, Toscano, Ana Luiza de Castro Conde, Silvestrini, Anderson Arantes, Rêgo, André Santa Bárbara, Wiermann, Evanius Garcia, Cunha Jr., Geraldo Felicio da, Melo, Heloisa Ramos Lacerda de, Morejón, Mirna Loro, Goldani, Luciano Zubaran, Pereira Jr., Luiz Carlos, Silva, Mariliza Henrique, Treistman, Mauro Sergio, Pereira, Mônica Cristina Toledo, Romero, Patricia Maria Bezerra Xavier, Schmerling, Rafael Aron, Guedes, Rodrigo Antonio Vieira, Camargo, Veridiana Pires de

Consensus of the Brazilian Society of Infectious Diseases and Brazilian Society of Clinical Oncology on the management and treatment of Kaposi's sarcoma

AUTOR(ES)

Arruda, Érico, Jacome, Alexandre Andrade dos Anjos, Toscano, Ana Luiza de Castro Conde, Silvestrini, Anderson Arantes, Rêgo, André Santa Bárbara, Wiermann, Evanius Garcia, Cunha Jr., Geraldo Felicio da, Melo, Heloisa Ramos Lacerda de, Morejón, Mirna Loro, Goldani, Luciano Zubaran, Pereira Jr., Luiz Carlos, Silva, Mariliza Henrique, Treistman, Mauro Sergio, Pereira, Mônica Cristina Toledo, Romero, Patricia Maria Bezerra Xavier, Schmerling, Rafael Aron, Guedes, Rodrigo Antonio Vieira, Camargo, Veridiana Pires de

FONTE

Braz J Infect Dis

DATA DE PUBLICAÇÃO

2014-06

RESUMO

Kaposi's sarcoma is a multifocal vascular lesion of low-grade potential that is most often present in mucocutaneous sites and usually also affects lymph nodes and visceral organs. The condition may manifest through purplish lesions, flat or raised with an irregular shape, gastrointestinal bleeding due to lesions located in the digestive system, and dyspnea and hemoptysis associated with pulmonary lesions. In the early 1980s, the appearance of several cases of Kaposi's sarcoma in homosexual men was the first alarm about a newly identified epidemic, acquired immunodeficiency syndrome. In 1994, it was finally demonstrated that the presence of a herpes virus associated with Kaposi's sarcoma called HHV-8 or Kaposi's sarcoma herpes virus and its genetic sequence was rapidly deciphered. The prevalence of this virus is very high (about 50%) in some African populations, but stands between 2% and 8% for the entire world population. Kaposi's sarcoma only develops when the immune system is depressed, as in acquired immunodeficiency syndrome, which appears to be associated with a specific variant of the Kaposi's sarcoma herpes virus. There are no treatment guidelines for Kaposi's sarcoma established in Brazil, and thus the Brazilian Society of Clinical Oncology and the Brazilian Society of Infectious Diseases developed the treatment consensus presented here.