Conformational aspects of antiviral activity of deoxyguanosine acyclic analogues.

AUTOR(ES)

Golbraikh, A A

RESUMO

Conformational possibilities of a series of deoxyguanosine analogues possessing or lacking antiviral activity were evaluated using methods of the molecular mechanics. Comparison of the spatial structures of acyclic analogues with one another and with the spatial structures of deoxyguanosine demonstrates restricted conformational mobility for compounds devoid of activity. The level of sterically allowed superposition of functional groups from the acyclic moieties of analogues and the corresponding atomic centres of deoxyribose could serve as a criterion of activity. The superposition could be performed in two different ways through either of the nonhydrogen substituents at the C1' atom in the five-membered ring.

Documentos Relacionados

• The antiviral activity of tetrazole phosphonic acids and their analogues.
• Antimicrobial activity of synthetic magainin peptides and several analogues.
• The reversible DNA-alkylating activity of duocarmycin and its analogues.
• The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues.
• Synthesis of some S-3'-deoxyadenosyl-L-homocysteine analogues.