Concentrations of various antibiotics in serum and fluids accumulated in diffusion chambers implanted in various sites in rabbits.
AUTOR(ES)
Georgopoulos, A
RESUMO
Diffusion chambers with Millipore membranes were implanted in soft tissue, kidneys, and peritoneal and pleural cavities of rabbits. Single doses of azlocillin, cefazolin, and gentamicin were injected intramuscularly and ampicillin was administered orally 2--5 weeks after implantation. The concentrations of the respective drugs in simultaneously collected samples of fluid from each diffusion chamber were measured and compared with concentrations found at the same time in serum. All chambers were tolerated well, and the method proved to be effective for collecting data on the distribution of drugs throughout the body.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283875Documentos Relacionados
- Fluid and Penicillin G Dynamics in Polyethylene Chambers Implanted Subcutaneously in Rabbits
- Treponema pallidum infection in subcutaneous polyethylene chambers in rabbits.
- Effect of Prolonged Fluconazole Treatment on Candida albicans in Diffusion Chambers Implanted into Mice
- Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits.
- Intra-articular yttrium 90 in rabbits. Comparison of behaviour of various radiocolloids in rabbits and in man.