COMPUTATIONAL STUDY OF THE INTERACTION BETWEEN INDENE PYRAZOLE AND CYCLIN DEPENDENT KINASE 2
AUTOR(ES)
Torres, Juan Enrique, Toro, Juan Pablo, Vergara, Javier, Baldiris, Rosa, Reyes, Ricardo Vivas
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2017-05
RESUMO
Proteins have been traditionally out of reach of electronic structure methods. But with technological advances in the development of powerful computers and the need to extend the methods of computational chemistry to problems of biological interest, such as the rational design of drugs, new technologies in silico have been developed that allow to study condensed systems of phase, which consist of thousands of atoms. Here, there are some techniques that combine two or more methods of calculating in a calculation that allows precise chemical exploration of very large systems. The aim of this work is to find the binding affinity of CDK2 inhibitors calculating their electronic densities and then comparing the similarities of these with the biological activity of ligands developing a QSAR in order to establish correlations between quantum similarity, which is a physical-chemical property and biological activity of said set of molecules that change their properties by varying any of their substituents.
Documentos Relacionados
- Regulation of the Interaction between Protein Kinase C-related Protein Kinase 2 (PRK2) and Its Upstream Kinase, 3-Phosphoinositide-dependent Protein Kinase 1 (PDK1)*
- Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
- The Rice Cyclin-Dependent Kinase –Activating Kinase R2 Regulates S-Phase Progression
- Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.
- Interaction of the S phase regulator Cdc18 with cyclin-dependent kinase in fission yeast