Comprimidos de ibuprofeno: formulação e avaliação do perfil de dissolução / Ibuprofen tablets: formulation and dissolution profile evaluation

AUTOR(ES)

Humberto Gomes Ferraz

DATA DE PUBLICAÇÃO

1993

RESUMO

Ibuprofen is a non steroidal antiinflamatory drug (NSAD), that has analgesic and antipyretic properties. It is used in terapeutic cases of mild to moderant pain, rheumatoid arthritis, osteoarthritis, and primary dysmenorrhea, in the 200, 300, 400, and 600 mg of concentration. In the Brazilian pharmaceutical market the formulation of 200 mg doesnt exist. In this study, a formulation of ibuprofen was developed for 200 mg tablets, that has suitable physical-chemical properties and an excellent dissolution profile. The eight formulations tested were obtained from factorial designs, evaluating several excipients. These formulations also had been submitted at room temperature, 37 ºC, and 50 ºC and were analised at 30 and 60 days, with the objective to evaluate the physical transformatiom that could have occurred during that time. The results were tested statistically by the STATGRAFCS program, using the exploratory analysis and the effects study. The final results showed that the best formulation was: IBUPROFEN - 200; STARCH - 47; LACTOSE - 72; MICROCRYSTALLINE CELLULOSE - 23; MAGNESIUM STEARATE - 8.

ASSUNTO(S)

dissolução ibuprofeno ibuprofen tablets dissolution comprimidos

Documentos Relacionados

• Biopharmaceutical evaluation of cephalexin tablets : dissolution kinetic and bioequivalence
• CARVEDILOL ESTUDOS DE ESTABILIDADE E PERFIL DE DISSOLUÇÃO
• Disintegration of Highly Soluble Immediate Release Tablets: A Surrogate for Dissolution
• Avaliação do perfil de dissolução de comprimidos de ciprofloxacino 250 mg comercializados como similares no Brasil
• Formulation of controlled-release baclofen matrix tablets: Influence of some hydrophilic polymers on the release rate and in vitro evaluation