Complicações motoras e não motoras na levodopaterapia na doença de Parkinson / Motor and non-motor complications in levodopa therapy in Parkinson s


IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia




Study the motor and non-motor complications in a group of patients with Parkinson´s disease (PD) treated with levodopa (LD). Motor and non-motor complications were assessed in 61 patients (22 women and 39 men) with PD using LD. The Unified Parkinson s Disease Rating Scale (UPDRS), Hoehn &Yahr staging and Schwab &England ADL scale were used to assess the patients "on/off" period. Motor and non-motor wearing-off effects were identified by the Wearing-off Questionnaire Card (QC). Depression was assessed by the Beck Depression Inventory and the perception of quality of life by the PD Quality of Life questionnaire (PDQ-39). The mean disease duration was 7.82±3.16 years. The mean age at onset was 56.70±9.38 years and the mean duration of levodopa (LD) treatment was 5.33±3.16 years. Motor fluctuations (MF) and dyskinesias were observed in 78.6% and 45.9%, respectively, of PD patients. The prevalence of MF was best predicted by the duration of levodopa treatment, the UPDRS "on" motor score and bodily discomfort (PDQ-39). The prevalence of dyskinesias was best predicted by disease duration. Motor symptoms were best identified by the QC. The most frequent nonmotor symptoms were anxiety, mood changes, aching and pain. Non-motor symptoms appeared along with motor symptoms. Conclusion: Motor fluctuations were related with greater motor impairment, bodily discomfort and duration of LD treatment. In addition, a correlation was found between dyskinesias and disease duration. Non-motor fluctuations occurred simultaneously with MF.


dopa (medicamento) discinesias depressão qualidade de vida levodopa dyskinesia depression quality of life

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