Comparison of specific and cross-reactive antigens of alphaviruses on virions and infected cells.
AUTOR(ES)
Gates, D
RESUMO
Rabbit hyperimmune antisera against Sindbis (SIN) or Semliki Forest (SF) virus were absorbed with purified SIN virus or SIN virus-infected cells, or with SF virus or SF virus-infected cells. Residual antibody titers were determined by hemagglutination inhibition (HAI) and antibody-dependent, complement-mediated cytolysis (ADCMC) assays. It appeared that absorption with virus-infected cells removed ADCMC-detectable cross-reactive antibody much more efficiently than did absorption with either virus. HAI assays with the same absorbed antisera indicated that both virus and virus-infected cells removed HAI-detectable cross-reactive antibody. On the basis of these and other data, there appeared to be a cross-reactive antigen present on virus-infected cells which was detectable by ADCMC and was distinct from the cross-reactive antigen assayed by HAI.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=351022Documentos Relacionados
- Cross-reactive cytotoxic T-lymphocyte-mediated lysis of Chlamydia trachomatis- and Chlamydia psittaci-infected cells.
- Stage-specific, strain-specific, and cross-reactive antigens of Leishmania species identified by monoclonal antibodies.
- Production of monoclonal antibodies that recognize specific and cross-reactive antigens of Fusobacterium nucleatum.
- Production of monoclonal antibodies that recognize specific and cross-reactive antigens of Bacteroides gingivalis.
- Identification of cross-reactive antigens between Mycoplasma pulmonis and Mycoplasma arthritidis.
