Comparison of replication of adenovirus type 2 and type 4 in human lymphocyte cultures.

AUTOR(ES)

Lambriex, M

RESUMO

Adenovirus type 2 was capable of replicating in purified lymphocyte cultures from human adenoid specimens. Phytohemagglutinin stimulation enhanced the replication of virus. Viral titers of 103 to 104 50% tissue culture infective doses per ml were reached after 4 to 8 days. Only 1 to 3 per 106 cells were found to produce virus. In contrast, there was no evidence that lymphocyte cultures could support the replication of adenovirus type 4. The life span of cultures infected with type 2 or 4 was not reduced. The possibility that lymphocytes infected with virus play a role in initiating natural, persisting adenovirus infections of human adenoids is discussed.

Documentos Relacionados

• Recovery of adenovirus type 7 from human brain cell cultures.
• Kinetics of cell death and disintegration in human lymphocyte cultures.
• Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures.
• Pluronic polyols in human lymphocyte cell line cultures.
• Beta-thalassaemia: increased chromosomal anomalies in lymphocyte cultures.