COMPARATIVE STUDIES OF THE MULTIPLICATION OF ANTIGENICALLY RELATED POXVIRUSES ON THE CHORIOALLANTOIC MEMBRANE OF THE CHICK EMBRYO

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Hahon, Nicholas (U. S. Army Chemical Corps, Frederick, Md.) and James J. Friel. Comparative studies of the multiplication of antigenically related poxviruses on the chorioallantoic membrane of the chick embryo. J. Bacteriol. 83:837–843. 1962.—A comparison was made of the general growth curves of several poxviruses, variola, alastrim, vaccinia, cowpox, rabbitpox, and monkeypox, on the chorioallantoic membrane of the chick embryo. All curves showed a lag period, followed by a tenfold increase of infectivity each 5 hr for approximately 20 to 25 hr, a peak growth level at 48 to 52 hr (except monkeypox), and a gradual decline after 72 hr.

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