Comparação entre o uso do plasma rico em plaquetas associado com aspirado de medular óssea ao enxerto autólogo de ilíaco na consolidação das osteotomias da tíbia proximal: estudo prospectivo randomizado / Comparison between platelet rich plasma associated with bone marrow aspirate to autologous iliac graft regarding bone healing in proximal tibial osteotomies: A prospective radomized study

AUTOR(ES)

Caio Oliveira D Elia

DATA DE PUBLICAÇÃO

2009

RESUMO

Introduction: The search for a bone substitute that makes unnecessary the harvest of autologous bone graft is a necessity of the orthopaedic surgeon. Bone marrow aspirate is rich in mesenquimal stem cells. The bone marrow aspirate contain mesenquimal stem cells that can differenciate in osteoblasts, being considered an osteogenic material. Platelet rich plasma contain several growth factors that have the capacity to promote and stimulate the differenciation of mesenquimal stem cells in osteoblasts improving the bone healing process, in other words platelet rich plasma has osteoinductive property. Objective: The aim of this study was to compare the occurrence of consolidation and the time taken to achieve this in cases of opening wedge osteotomy of the tibia, between autologous iliac grafts and platelet rich plasma with bone marrow aspirate. Methods: Twenty-five patients who underwent opening wedge osteotomy were studied. They were randomly divided into two groups: a control group of 14 patients wich received autologous iliac grafts and a study group of 11 patients wich received a compound of platelet rich plasma and bone marrow aspirate. Results: The consolidation rates achieved were 100% in the iliac group and 91% in the platelet-rich plasma group (p = 0.440). There was no difference in the time taken to achieve consolidation between the groups (p = 0.129). Conclusion: The use of platelet rich plasma with bone marrow aspirate as a bone substitute was shown to be effective in achieving consolidation in tibial osteotomies and in the time necessary to achieve this when compared to autologous iliac graft .

ASSUNTO(S)

plasma rico em plaquetas osteotomia platelet rich plasma tibia. peptídeos e proteínas de sinalização intercelular osteotomy interceular signalizing proteins bone substitutes substitutos ósseos tibia

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